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Spravato is an FDA-approved nasal spray for the treatment of depression, specifically for patients with treatment-resistant depression (TRD).

Esketamine works by blocking N-methyl-D-aspartate (NMDA) receptors in the brain, which can increase the activity of certain neurotransmitters, including glutamate. This increased activity has been shown to have a positive effect on mood and alleviate depressive symptoms.

Spravato is usually used in conjunction with an oral antidepressant medication and is administered under the supervision of a healthcare professional.

Integration Therapy is an emerging treatment for depression, anxiety, PTSD, and other mental health conditions that combines the use of ketamine, a dissociative anesthetic, with psychotherapy.

In Integration Therapy a patient is given a controlled dose of ketamine in a therapeutic setting, under the supervision of a trained therapist. The patient then undergoes a psychotherapy session, which helps them process and integrate the insights and experiences they have while under the influence of ketamine.

Integration Therapy is a holistic approach to healing that aims to address not just the symptoms of mental health conditions, but also the underlying psychological and emotional  that contribute to them. By combining the powerful effects of ketamine with the insights and support of psychotherapy, Integration Therapy can help patients achieve lasting improvements in their mental health and well-being.